The Diagnosis of Tuberculosis

Directions for the students: There are 4 essay questions. Please be sure to complete all of them with thorough substantive responses. Citations are required for all responses. There is no time limit.1. Individuals who smoke have much higher rates of lung infection. Explain which first-line defenses mechanisms may be impaired by smoking, allowing pathogens to more readily enter the lower respiratory tract.2. The diagnosis of tuberculosis involves the observation of lung structures called tubercles on an X ray. What immunologic process leads to the formation of tubercles, and what type of immune cells may comprise these lesions?3. Provide an explanation in support of or refuting the following statement: “Humans would never develop natural immunity to a novel biological agent created in a laboratory.”4. Explain how super-antigens, such as toxic shock syndrome toxin produced by Staphylococcus aureus, often lead to the development of life-threatening symptoms in an infected individual.